Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. AUTHORS
نویسندگان
چکیده
AFFILIATIONS: 1 Research foundation, University General Hospital Consortium, Valencia, Spain 2 Department of Biotechnology, Universidad Politécnica de Valencia CIBERES, Health Institute Carlos III, Valencia, Spain Respiratory Unit, University General Hospital Consortium, Valencia, Spain Department of Medicine, Faculty of Medicine, University of Valencia, Spain Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
منابع مشابه
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is characterised by the aberrant epithelial to mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate (S1P) and sphingosine kinase 1 (SPHK1) have been implicated in lung myofibroblast transition, but their role in EMT and their expression in patients with IPF is unknown. METHODS AND RESULTS S1P levels were measured i...
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